Eu Project INFEMAT on Haemophilus influenzae type b (Hib)
Within the framework of the INFEMAT project, we created an individual-based computer model which allows to simulate the dynamics of Haemophilus influenzae type b infection. The simulated individuals are grouped in families and are assumed to live in "neighbourhoods". Depending on their age, they attend kindergarten groups, school classes or have a work place. Transmission of the infection may occur in any one of these places. Newly infected individuals develop a latent infection and then become infectious for a variable period of time. The infection causes a rise in specific antibodies, which depends on the age at infection. The individul is resistant to any subsequent infection as long as his or her antibody titre is above a certain treshold. As long as the individual's antibody titre is above a second (lower) treshold, he or she is also protected against disease.